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Filed Under: HEALTH, TECHNOLOGY

$2 million grant for revolutionary rehabilitation technology

Dr Dinesh Palipana (left) and Dr Claudio Pizzalato

BioSpine research towards a spinal injury cure

A world-leading program led by Griffith University researchers Dr Dinesh Palipana OAM, Queensland’s first quadraplegic medical doctor, and research fellow Dr Claudio Pizzolato has potential to completely transform the way spinal injury patients are rehabilitated, with application for other forms of rehab as well.

The promising research, which uses novel personalised medicine technology to bring together the most promising approaches to treating spinal cord injury in human history, has secured a $2 million funding injection from the Motor Accident Insurance Commmission (MAIC).

With very personal motivation to make a difference, Dr Palipana says he is grateful the stars are aligning on the Gold Coast to create a holistic treatment that will help patients all around the world.

“We are using thought control, electrical simulation, and drug therapy in an attempt to restore function in paralysis.”

Dr Claudio Pizzolato says the research was inspired by work underway in Europe and the USA and centred on their world-first personalised ‘digital twin’ that brings a brain-computer interface together with a human-machine interface to ‘close the loop’ broken by spinal cord injury.

“Our approach involves collaborating with spinal cord injury patients, clinicians, researchers, and engineers from the beginning in order to create a technology that works and is easy to use in clinics and hospitals,” he said.

“The MAIC funding is an incredible opportunity to create disruptive technologies that have the potential to change people’s lives.”

Griffith Vice Chancellor and President Professor Carolyn Evans welcomed the generous support from MAIC and says it would enable a transformative research opportunity.

“Rehabilitation for spinal cord injury has traditionally been quite slow and limited, and even with recent advances in robotic rehabilitation equipment has not been personalised to the patient or combined with thought control,” Professor Evans says.

“MAIC’s commitment to this world-leading research is in addition to previous financial support for promising research into a regenerative medicine treatment for the injured spinal cord through stem cell transplantation. Funding for both innovative initiatives will help cement the university’s reputation in spinal cord injury research.”

Dr Dinesh Palipana, Professor David Lloyd, Dr Claudio Pizzalatto and Perry Cross of the Perry Cross Spinal Injury Foundation

The Biospine project is a key Griffith University led initiative which is anticipated will help position the Gold Coast Health and Knowledge Precinct (GCHKP) as a global leader in spinal injury rehabilitation.

Research will be carried out at ADaPT 1.0 with ADaPT 2.0 to be built within the GCHKP by 2022.

Learn more

December 3, 2019 By Kathy Kruger

Filed Under: HEALTH, TECHNOLOGY Tagged With: 3d printing, ADaPT, Dr Hal Rice, Dr Sam Canning, Neuroendovascular, Neurovascular, Stryker

High-tech training centre opportunity in life-saving procedures

Dr Sam Canning (left) from Griffith University and Dr Hal Rice from GCUH

In the most delicate and exacting of procedures, world-leading Interventional Neuroradiologist Dr Hal Rice routinely saves lives at the Gold Coast University Hospital (GCUH) – and now with ground-breaking help from 3D printing experts in the Precinct is set to train specialists from around the world.

Dr Rice, together with colleague Dr Laeticia de Villiers, extracts blood clots from inside blocked blood vessels in stroke patients and repairs fragile brain aneurysms that have ruptured or are at high risk of rupturing with catastrophic brain haemorrhage.

The specialist in minimally-invasive endovascular neurosurgical procedures navigates a series of tiny plastic tubes from the femoral artery in the patient’s groin or radial artery in the wrist up into brain blood vessels measuring only two to three millimetres wide, to gently remove blood clots or reconstruct swollen and ruptured blood vessels using innovative devices such as ultra-fine platinum coils and vascular stents, without the need to cut through the skull.

Many of the devices are made by leading global medical company Stryker, with Dr Rice’s world-class standing attracting Stryker’s President of Neurovascular Mark Paul and company executives from the region to visit the Precinct, with a view to using it as their Asia-Pacific base for specialised training.

 

The visiting Stryker delegation hosted by Dr Hal Rice

3D printed models take planning and training to new levels of precision

Working with advanced imaging and the specialist digital design skills of Griffith University ADaPT (Advanced Design and Prototyping Technology) experts, they’re 3D printing exact replicas of an individual patient’s aneurysm in situ within the blood vessel so they can better plan life-saving surgeries and train other specialists in this precision specialised medicine.

Conventional training has relied on animal models – the high-tech approach blending virtual simulation with replica printed models will be world-first.

‘The 3D printed models help us to very realistically simulate these complex lifesaving procedures, bringing to life what we see on screen in the operating theatre during an actual treatment,’ says Dr Rice.

‘With a large inventory of precisely printed 3D models we can now rehearse treatment plans and also train specialists in the latest technologies, while using the models to rigorously evaluate new and future products before commencing clinical trials. The models can even be fitted with special pumps to realistically mimic normal pulsating blood flow.’

Dr Rice shows Federal Health Minister Greg Hunt large and life-size versions of the 3D printed models

For Dr Sam Canning, Convenor of Digital and 3D Design at Griffith University, the project tests the limits of design and prototyping technologies.

‘With a project of this complexity we are breaking new ground. We’ve conducted exhaustive tests of combinations of imaging technologies, 3D modelling/imaging software and extensive exploration of 3D printing technologies,”Dr Canning says.

I think it is safe to say that it is recent advances in imaging, software and hardware that have made this entire project possible. Most of this technology (in its current form) did not exist only eighteen months ago.”

October 8, 2019 By Kathy Kruger

Filed Under: PROJECTS, TECHNOLOGY

Beyond spinal cord injury – research brings hope on World SCI day

Assoc Professor James St John and his team are working on a biological treatment for SCI

On World Spinal Cord Injury (SCI) Awareness Day, the Precinct’s BIOSPINE project, led by Griffith University biomechanical engineer Professor David Lloyd, is close to finalising a large research contract that is set to position the GCHKP as a global leader in spinal injury rehabilitation.

With industry and philanthropic support already locked in, a team of 15 researchers primarily from Griffith and including collaborators from Harvard and the University of Sydney are set to take promising research, founded on their novel digital twin platform technology – ‘Personalised Digital Human’, to the next exciting step towards a spinal injury cure.

The flagship project is just one being pursued by Professor’s Lloyd’s team within an international group of more than 90 collaborators developing next-generation intelligent approaches to training, treatment, surgery planning and rehabilitation, addressing neuromusculoskeletal (neurological and orthopaedic) and vascular (cardio and neuro vascular) conditions.

Meanwhile a 30-strong team in the Precinct’s Clem Jones Centre for Neurobiology and Stem Cell Research, also at Griffith University, is refining research that has already been successful in regrowing spinal nerve tissue in some animal models.

Professor David Lloyd (standing), Dr Dinesh Palipana and Dr Claudio Pizzalato

Novel approach to neurorehabilitation

The BIOSPINE project has the support of a Perpetual IMPACT funding grant of $138,000, and researchers will work with US-based Restorative Therapies (Maryland), the industry leader in integrated functional electrical stimulation (iFES), and Making Strides, a Gold Coast-based leading Australian rehabilitation provider for SCI patients.

Restorative Therapies has successfully worked with more than 100,000 SCI, Stroke, MS, Cerebral Palsy and Traumatic Brain Injury patients in 1,000 clinics and 4,000 homes over the past 15 years and will supply equipment and software to BIOSPINE – an FES stimulator and RT300 iFES Leg Neurological Rehabilitation system.

Making Strides will translate the research through patient therapy.

Professor Ted Teng, of Harvard University School of Medicine and leading US facility Spaulding Rehabilitation Hospital, will provide pharmaceutical pairing for neurorestoration to enhance the effects of the intelligent physical therapy.

It’s hoped Professor Lloyd’s project can also integrate with the biologics work of Associate Professor James St John’s team on the Spinal Injury Project for a complete approach to SCI recovery.

Biologics hold out hope of cure

Mayor Tom Tate and benefactor Perry Cross (Perrry Cross Foundation) tour a specialised research laboratory

The Spinal Injury Project is a group of scientists, engineers, medical doctors, veterinarians and educators at Griffith University all working together to develop a cell transplantation therapy to treat traumatic spinal cord injuries.

The therapy involves the transplantation of Olfactory Ensheathing Cells (OECs) – a specialised type of cell from the nose, into the spinal cord to help the guidance and regrowth of nerve cells across the injury site.

Recent progress has demonstrated that transplanting a nerve bridge made of the OECs results in the nerve cells growing across the injury site in animal models. The therapy works in some animals, but not all, and work is ongoing to improve the therapy so that a wider range of injuries can be treated more consistently and it can proceed to clinical trials.

September 5, 2019 By Kathy Kruger

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Healthtech Summit celebrates a future of personalised medicine, AI and hope image

Healthtech Summit celebrates a future of personalised medicine, AI and hope

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