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News

Filed Under: BUSINESS, INVEST Tagged With: Dubai, Dubai Academic Health Corporation, Dubai Futures Foundation, Mohammed Bin Rashid University of Medicine and Health Sciences

Precinct set to partner with Dubai

I hope you all have had a great start to 2023.

I wanted to provide our Gold Coast Health & Knowledge Precinct network with an insight into the business development work undertaken by the Precinct Office, in conjunction with our key partners.

Specifically, this article is focused on my recent visit to Dubai.

By way of background, the Gold Coast and Dubai have held a Sister City relationship for the past 22 years. People from Dubai love visiting the Gold Coast. During their summer months, the Gold Coast is a highly popular destination for people from the Middle East. Whilst I was in Dubai, many people knew of the Gold Coast and told me of their great family holidays to our city. It’s these relationships that provide a foundation for the Gold Coast and Dubai to progress new business relationships.

Dubai is fast becoming a global city powerhouse, with their vision to make Dubai one of the world’s foremost future cities. They are investing significantly in infrastructure, energy, transportation, ICT, education, security and health. They are creating partnerships globally and bringing some of the most highly qualified experts to work in Dubai. Through the Sister City relationship, Dubai can connect the Gold Coast into a global network of innovation.

Mayor Tom Tate

My visit to Dubai was specifically to follow on from Mayor Tom Tate and City of Gold Coast CEO Tim Baker’s visit in November 2022. During their visit, health was identified as a key priority for Dubai.

Therefore, I travelled to Dubai and pitched five of the Gold Coast’s leading health technologies to the Dubai Futures Foundation, Dubai Academic Health Corporation and the Mohammed Bin Rashid University of Medicine and Health Sciences. These projects included:

  1. Artificial intelligence in healthcare
  2. Image guided and robotic treatment for stroke and aneurysm
  3. Drugs, vaccines and diagnostics
  4. Advanced rehabilitation with a focus on spinal injury
  5. Orthopedic surgery techniques.
BioSpine is a key technology for partnership opportunities in Dubai

Post my visit, I am now in regular contact with the stakeholders I met with and in the process of connecting and facilitating our local Gold Coast experts to meet with associated Dubai stakeholders. It is our intent that by introducing these Gold Coast capabilities to Dubai, that new partnerships and investment can be facilitated, to fast-track these technologies for the benefit of Gold Coast, Dubai and beyond.

These efforts in the health sector, if progressed successfully will build further opportunities in the other key priority sectors for Dubai identified above.”

This visit could not have been undertaken without the support of Trade and Investment Queensland’s Geoffrey Schuhkraft. His relationships and commitment to our city is exceptional.

I hope this piece gives you an insight into the work done by the Precinct Office in promoting our leading Gold Coast technologies and showcasing our talent internationally.

Best,

Craig

March 1, 2023 By Kathy Kruger

Filed Under: HEALTH, TECHNOLOGY Tagged With: artificial heart, BiVACOR, Cohort, Griffith Mechanobiology Lab, Griffith University, Medtech

BiVACOR wins new grant for artificial heart development

BiVACOR researchers in the Precinct will focus on a next-generation external device controller as part of their development of a world-first Total Artificial Heart (TAH), supported by a $750k grant from the Australian Government through its Medical Research Future Fund (MRFF) and Targeted Translation Research Accelerator (TTRA) program.

As the company heads towards first-in-human clinical trials within the next two years, the grant, matched by in-kind support bringing approximately AUD$2.2 million in funding towards BiVACOR’s clinical advancement, will help develop a lighter, smaller, more portable external controller to give patients better quality of life at home.

External heart controller development to improve patient comfort

BiVACOR’s novel TAH technology is the first long-term therapy dedicated to patients with severe biventricular heart failure.

The implantable total artificial heart, the size of a human fist, is based on a rotary blood pump and uses magnetic levitation (MAGLEV) technology to enable the double-sided centrifugal impeller to rotate in free-space, minimising blood trauma and eliminating mechanical wear.

Dr Daniel Timms with the BiVACOR TAH

A long labour of love for founder and Chief Technology Officer (CTO) Dr Daniel Timms, the BiVACOR TAH has enjoyed significant Australian government support over its two decades of R&D.

“Heart failure hits close to home for me. It remains a leading cause of death worldwide, and its prevalence is only increasing,” says Dr Timms, who lost his father to the disease.

 “BiVACOR is an Australian-born innovation, and we are extremely grateful for the ongoing support from the Australian government and community.

Without their support, we wouldn’t be where we are today, and this grant gives us a boost in the clinic to drill down into the TAH external controller.”

The TTRA program, a MRFF initiative delivered by MTPConnect, supports new approaches to improve the prevention, dianosis, treatment and management of diabetes and cardiovascular disease complications.

Griffith researchers work on testing the BiVACOR TAH for its blood compatibility

While the implantable device is largely being developed in the US, including through collaboration with the Texas Heart Institute, the latest version heading towards clinical trials has been extensively tested at Griffith University’s Mechanobiology lab, with the aim of understanding and reducing its impact on blood cells.

Across the road at Cohort, where BiVACOR bases its international office, research engineers are focused on the heart’s external controller and its software.

“We want a controller that is as small, lightweight and as ergonomic as possible to maximise portability and comfort,” explains Dr Timms.

“At the same time, it needs to be totally reliable, including its batteries and power system, and we want to create a software interface that enables patients to easily monitor and manage their cardiovascular health, while providing timely and reliable data and alerts to their clinicians when needed.”

During the planned first-in-human trials, patients implanted with the TAH will remain in hospital for monitoring, whilst waiting for a human heart transplant.

“Our goal is to provide the best possible solution for patients facing end-stage heart failure who have run out of options,” says BiVACOR CEO Dr Thomas Vassiliades.

“These funds will give us a clinical advantage as we push on perfecting the external controller for the TAH.”

The BiVACOR TAH builds on the successful transition of Left Ventricular Assist Device (LVAD) technology from volume displacement to durable rotary blood pumps and aims to be the next-generation TAH that sufficiently restores quality of life to patients suffering from severe biventricular heart failure.

The TAH therapy may be initially utilised as a short-term device in a patient awaiting a heart transplant or as a long-term alternative to heart transplantation.

To date, BiVACOR has raised more than AUD$50 million in funding.

February 8, 2023 By Kathy Kruger

Filed Under: BUSINESS, HEALTH, TECHNOLOGY Tagged With: BioAz, Cohort, food tech, health tech

Food tech brings nature’s intelligence to synergistic Precinct ecosystem

The Bio-az lab at Cohort

Functional food tech scale-up and LuminaX 2022 graduate Bio-az, is on a mission to bring back wellness to food and beverages at a time when processed foods have stripped our diets of the natural ingredients we need for good gut and overall health. Having been awarded the NutraIngredients-Asia Start-up of the Year in 2021, the company has the science to back what they believe is a world-first synbiotic ingredient – combining prebiotics, probiotic microbes and postbiotics – that amplifies wellness.

The synbiotic platform Bio-az has developed – based on their team’s many decades of combined expertise in microbiology and food science – combines the best prebiotics, probiotic microbes and postbiotics in an optimal way. These millions of beneficial bacteria work together synergistically in the digestive system and within the entire body Microbiome, hence the name ‘synbiotic’.

“It’s all about creating the right ecosystem,” explains Bio-az CEO Maryann Thexton, who says Bio-az has found a great innovation ecosystem since setting up its laboratory at Cohort and taking part in this year’s LuminaX Accelerator.

“A healthy Microbiome provides a foundation of good health – there is a lot of science to support this now.”

The Bio-az core team of five began bringing the science behind Synbiotics together in 2018, sharing a common vision to ‘embed the wellness of synbiotics into everyday foods’ and waiting until 2020 to incorporate as a company (formerly known as Marl Corporation) and begin commercialisation.

Bio-az CEO Maryann Thexton

“It was important for us to take the time to get the science right in what is a rapidly emerging field,” says Thexton.

While scientists, and to a varying extent consumers, have understood the benefits of probiotics for some time and come to discover more about the role of pre-biotics, understanding the value of post-biotics (inanimate or so-called ‘dead cells’) is a more recent development. And putting them all together in a complimentary way makes all the difference.

This requires a marriage of microbiology with food technology to create stable and effective microbial ingredient blends that don’t negatively impact flavour, are able to withstand variables such as temperature change and that are commercially and logistically viable in a range of  ‘fridge free’ products – a key innovation. While there’s a lot of modern technology involved in formulating, the understanding behind the benefits of ingredients for a healthy Microbiome is ancient.

“Cultures all over the world have been fermenting foods for thousands of years and using peat and bog to achieve good microbial environments for food cultivation,” says Thexton.

Our modern food processing system has killed off good microbes and over-sanitised our foods, and people can relate to that.”

While acknowledging the element of scepticism felt by consumers navigating a crowded functional foods market, she says doing the R&D and publishing results to satisfy the FSANZ (Food Standards Code) has been critical for Bio-az, as is a partnership with German-based global natural ingredients distributor Döhler to find the right partners to work with in incorporating their synbiotic ingredients into the right products.

Human health is the focus, but Bio-az also produces pet blends – and what’s good for the horse (Thexton has a long background in animal health and specifically the Equine industry) isn’t necessarily good for the dog. The same goes for humans – what’s good for Peter, may not be just right for Paula.

In humans they can design symbiotic microbial blends focused on different health aims – the overall objective being to fight ‘baddies’ and strengthen the body’s immune system while nurturing the ‘goodies’ – but also more specifically to influence targeted health and nutritional requirements in the future.

Bio-az co-founder Lynette Rouse and CEO and co-founder Maryann Thexton

Aside from their powdered ingredients, Bio-az has produced its first synbiotic consumer product – Bioitica Water. Their customer Naked Life has introduced synbiotics into the burgeoning non-alcoholic distilled botanical beverages market through two products, Glow and Immunity, currently available in supermarkets

The Bio-az team want to help improve children’s health through introducing their ingredients into dried fruit and other kids snacks, while another pillar of the company is developing microbial blends for wound healing and skincare.

Even chocolate is set to get a microbial makeover!

Thexton, who is the only non-scientist in the foundation team, tries to achieve the right balance between science and business in their growth plans, and says the LuminaX program was both a valuable learning and re-learning process.

“Bio-az was a little more advanced as a company than some of the other start-ups involved, however we still got insights out of every workshop or mentoring session, whether it be learning something new, reinforcing existing knowledge or just benefiting from the energy and diverse ideas of peers in different areas of the healthtech sector,” she says.

Now with their lab location grounding them in the Precinct’s growing innovation system, BioAZ is confident it has the recipe for success in a highly-competitive global market.

Meanwhile, we’ll also drink to related exciting news, that Griffith University researchers in the Precinct have helped put postbiotics into coffee, in a partnership with CSIRO and local company Coffee Roasters Australia.

October 14, 2022 By Kathy Kruger

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