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Filed Under: BUSINESS, HEALTH, TECHNOLOGY Tagged With: BioAz, Cohort, food tech, health tech

Food tech brings nature’s intelligence to synergistic Precinct ecosystem

The Bio-az lab at Cohort

Functional food tech scale-up and LuminaX 2022 graduate Bio-az, is on a mission to bring back wellness to food and beverages at a time when processed foods have stripped our diets of the natural ingredients we need for good gut and overall health. Having been awarded the NutraIngredients-Asia Start-up of the Year in 2021, the company has the science to back what they believe is a world-first synbiotic ingredient – combining prebiotics, probiotic microbes and postbiotics – that amplifies wellness.

The synbiotic platform Bio-az has developed – based on their team’s many decades of combined expertise in microbiology and food science – combines the best prebiotics, probiotic microbes and postbiotics in an optimal way. These millions of beneficial bacteria work together synergistically in the digestive system and within the entire body Microbiome, hence the name ‘synbiotic’.

“It’s all about creating the right ecosystem,” explains Bio-az CEO Maryann Thexton, who says Bio-az has found a great innovation ecosystem since setting up its laboratory at Cohort and taking part in this year’s LuminaX Accelerator.

“A healthy Microbiome provides a foundation of good health – there is a lot of science to support this now.”

The Bio-az core team of five began bringing the science behind Synbiotics together in 2018, sharing a common vision to ‘embed the wellness of synbiotics into everyday foods’ and waiting until 2020 to incorporate as a company (formerly known as Marl Corporation) and begin commercialisation.

Bio-az CEO Maryann Thexton

“It was important for us to take the time to get the science right in what is a rapidly emerging field,” says Thexton.

While scientists, and to a varying extent consumers, have understood the benefits of probiotics for some time and come to discover more about the role of pre-biotics, understanding the value of post-biotics (inanimate or so-called ‘dead cells’) is a more recent development. And putting them all together in a complimentary way makes all the difference.

This requires a marriage of microbiology with food technology to create stable and effective microbial ingredient blends that don’t negatively impact flavour, are able to withstand variables such as temperature change and that are commercially and logistically viable in a range of  ‘fridge free’ products – a key innovation. While there’s a lot of modern technology involved in formulating, the understanding behind the benefits of ingredients for a healthy Microbiome is ancient.

“Cultures all over the world have been fermenting foods for thousands of years and using peat and bog to achieve good microbial environments for food cultivation,” says Thexton.

Our modern food processing system has killed off good microbes and over-sanitised our foods, and people can relate to that.”

While acknowledging the element of scepticism felt by consumers navigating a crowded functional foods market, she says doing the R&D and publishing results to satisfy the FSANZ (Food Standards Code) has been critical for Bio-az, as is a partnership with German-based global natural ingredients distributor Döhler to find the right partners to work with in incorporating their synbiotic ingredients into the right products.

Human health is the focus, but Bio-az also produces pet blends – and what’s good for the horse (Thexton has a long background in animal health and specifically the Equine industry) isn’t necessarily good for the dog. The same goes for humans – what’s good for Peter, may not be just right for Paula.

In humans they can design symbiotic microbial blends focused on different health aims – the overall objective being to fight ‘baddies’ and strengthen the body’s immune system while nurturing the ‘goodies’ – but also more specifically to influence targeted health and nutritional requirements in the future.

Bio-az co-founder Lynette Rouse and CEO and co-founder Maryann Thexton

Aside from their powdered ingredients, Bio-az has produced its first synbiotic consumer product – Bioitica Water. Their customer Naked Life has introduced synbiotics into the burgeoning non-alcoholic distilled botanical beverages market through two products, Glow and Immunity, currently available in supermarkets

The Bio-az team want to help improve children’s health through introducing their ingredients into dried fruit and other kids snacks, while another pillar of the company is developing microbial blends for wound healing and skincare.

Even chocolate is set to get a microbial makeover!

Thexton, who is the only non-scientist in the foundation team, tries to achieve the right balance between science and business in their growth plans, and says the LuminaX program was both a valuable learning and re-learning process.

“Bio-az was a little more advanced as a company than some of the other start-ups involved, however we still got insights out of every workshop or mentoring session, whether it be learning something new, reinforcing existing knowledge or just benefiting from the energy and diverse ideas of peers in different areas of the healthtech sector,” she says.

Now with their lab location grounding them in the Precinct’s growing innovation system, BioAZ is confident it has the recipe for success in a highly-competitive global market.

Meanwhile, we’ll also drink to related exciting news, that Griffith University researchers in the Precinct have helped put postbiotics into coffee, in a partnership with CSIRO and local company Coffee Roasters Australia.

October 14, 2022 By Kathy Kruger

Filed Under: HEALTH, INVEST, PROJECTS, TECHNOLOGY Tagged With: Dr Hal Rice, Dr Laetitia de Villiers, image-guided surgery, NorthWest, Philips

Global healthcare leader Philips backs high-tech medical training centre in Precinct

Dr Hal Rice, Director Interventional Neuroradiology, GCUH with Dr Atul Gupta, Chief Medical Officer, Philips Image-Guided Therapy and Dr Laetitia de Villiers, Interventional Neuroradiologist, GCUH

Global healthcare technology leader Philips will partner in a unique, cutting-edge research and training centre in the Gold Coast Health and Knowledge Precinct, where its latest image-guided therapy technology will support training specialist physicians from across the Asia-Pacific and pioneer new precision approaches in a wide range of clinical areas – from cardiovascular disease to stroke, cancer, and spine conditions.

Led by interventional neuroradiologists Dr. Hal Rice and Dr. Laetitia de Villiers, who deliver the latest innovative treatments for stroke and brain aneurysms at Gold Coast University Hospital (GCUH), the facility will showcase Philips’ interventional solutions and trial new technologies such as artificial intelligence (AI), robotics and novel 3D printed anatomical models.

The pilot centre is also being supported by NorthWest Healthcare Properties, ahead of moving into their proposed state-of-the-art new building, ‘RDX Lumina’, on a prominent GCHKP site in the Lumina commercial cluster.

Read the Philips story here.

It’s a centre that represents a revolutionary step in medical education and new technology development to drive the future of minimally-invasive patient care.

Building on a strong track-record of delivering specialised training and conducting world and Australian-first clinical trials at GCUH over the last decade, including a world-first robotic stroke clot removal, Dr. Rice says the facility will be a unique space just for training and technology development.

“This dedicated facility will have the latest equipment and space to accommodate larger groups, without the constraints of prioritising patient care within a busy hospital environment,” Dr. Rice says.

“Importantly we’ll be able to expand our research and development (R&D) in the neurovascular field, while broadening training in other surgical specialties, widely utilising 3D printed models to revolutionise training and looking to a future where AI and robotics will enable remote procedures, virtually anywhere in the world.”

It is incredible to have Philips’ support as our key technology partner and to also be able to bring other leading medical device companies to our facility to join forces in R&D.”

Artist render of the new centre
The latest Philips Azurion biplane system for image-guided therapies

Philips will equip the centre with their Azurion biplane system, a leading platform for interventional procedures, favoured for its intuitive, seamless approach that enables clinicians to focus on treating the patient. The latest version of Azurion takes a further leap in integrating essential lab systems and tools into one platform.

Interventional radiologist and Philips’ Chief Medical Officer for Image Guided Therapy Dr. Atul Gupta said that the global reputation of Dr. Rice and Dr. de Villiers was key to the decision to collaborate in the centre.

“Optimising the workflow across the entire care pathway offers the best chance of improving outcomes for patients with neurological conditions such as stroke and cerebral aneurysms,” says Dr. Gupta.

“One patient, every single second, somewhere on earth has their life improved, or sometimes saved, thanks to one of Philips’ image-guided therapy devices or systems.

It is super important for us to collaborate with leading physicians like Dr Rice and Dr de Villiers here in the Gold Coast Health and Knowledge Precinct, because they are so actively involved in pushing the envelope with neurovascular disease – stroke and cerebral aneurysm care.

We have clinical sites all over the world, 500, 600 clinical sites, but what makes this site so unique is that it is not in a hospital, this freestanding facility is purely focused on education and R&D without having patient care get in the way, which will amplify access to education and training, and furthermore, by virtue of it being on the Gold Coast, is a key hub to access a huge part of the world – the entire Asia-Pacific region.”

The GCHKP location represents an added opportunity to create collaborations with Griffith University researchers, other clinicians and industry partners.

Dr. de Villiers said the new centre would be equipped to enable live links to theatre suites, including a new suite being established at Gold Coast Private Hospital,  for training doctors to be able to review and then replicate complex procedures.

Life-like 3D printed models will revolutionise training

“They will be able to practice on exact 3D printed replica models of the brain blood vessels of patients whose procedures they have just watched us undertake, utilising the state-of-the-art Philips image guidance system,” says Dr. de Villiers.

“They will also be able to rehearse their own patient cases on personalised patient models that accurately simulate the feeling of pulsing blood, that we can 3D print in advance of training, and we can guide them through these difficult procedures.”

Dr Gupta sees an exciting future for image-guided therapies:

I think the future is going to be an inteventional suite powered by even better imaging, perhaps essentially imaging without raditation. We’re going to have even smaller endovascular devices for treatment of cardiovascular disease and its going to be empowered by artificial intelligence, augmented reality and procedural automation”

Pilot facility to be expanded into proposed new building

The new centre, which will also be equipped with high-quality audiovisual and high-speed data links, has been enabled through a substantial fit-out of an existing GCHKP legacy building in the Lumina commercial hub, supported by NorthWest Healthcare Properties, ahead of the proposed development of their ultimate facility – ‘RDX Lumina’. RDX Lumina is planned as a world-class life science, research and innovation focused building. The eight-storey facility will be targeting a 6 Star Green Star rating, a first for the Lumina precinct.

Architectural render of the proposed RDX Lumina building

NorthWest Vice President – Leasing, Georgie Huxley, says of the development: “NorthWest specialises in the development and ownership of market-leading health and life sciences properties and precincts, where we combine complementary facilities and the best medical experts in the field to create a hub of the highest quality healthcare offering possible. RDX Lumina is a great example of the intersect between research, innovation, healthcare and clinical training, led by the involvement of industry leaders Dr. Rice and Dr. de Villiers.

We are proud to be delivering this innovative training facility via our team of Australia’s healthcare real estate experts, as the largest specialist healthcare real estate operator in the country by a considerable margin, leading the way in building design and delivery for this eminent site.”

August 17, 2022 By Kathy Kruger

Filed Under: HEALTH, Research, TECHNOLOGY Tagged With: ADaPT, biomedical engineering, fresh scientist awards, GCore, Medtech

‘Queensland Fresh Scientist’ slashes surgery times for young patients

Dr Martina Barzan holding a hip bone anatomical model

The Precinct’s latest ‘Queensland Fresh Scientist’ is helping to slash surgery times and improve outcomes for paediatric patients undergoing complex procedures to correct hip deformities, by modelling surgeries, and designing and 3D printing personalised anatomical models and cutting guides.

Dr Martina Barzan is the 2021 Queensland Fresh Scientist award winner, joining fellow researchers from Griffith University’s Centre of Biomedical and Rehabilitation Engineering (GCore) to secure a hat-trick with awards in 2019 (Dr Antony McNamee) and 2018 (Dr Claudio Pizzolato). No competition was held in 2020 due to Covid.

Bioengineer Martina Barzan is in good company with her GCore colleagues – all focused on improving lives through precision medicine.

In the recent Queensland Fresh Science Awards, she took on 11 other up-and-coming scientists, to describe their scientific discoveries in less than a minute.

“Imagine if your little sister, daughter, or niece could not walk, or even sit, due to hip pain caused by a severe bone deformity,” Dr Barzan pitched. “The only treatment is surgery.”

Every two days, one child in Queensland has surgery to correct hip deformities.”

Dr Barzan plans a surgery with Assoc Prof Chris Bade

Traditionally, surgeons rely on 2D scans to guide surgery planning. Dr Barzan’s approach is to create a 3D digital twin – a computerised replica of a child’s anatomy, with the bones and muscles attached. The digital twin allows surgeons to test surgery options and simulate how the child’s hip would move after surgery.

After finalising their preferred surgical approach, Dr Barzan works with Griffith’s Advanced Design and Prototyping Technology Institute to design and 3D print cutting guides precisely matching the child’s bone shape, to transfer the virtual plan to the operating room.

“Surgery times and radiation doses have been cut in half and, nine months after surgery on the 13 children in our clinical trial, all can sit and walk again,” she says.

The approach is now being applied commercially and is already saving money for hospital services through reduced theatre costs and post-surgery follow-up.

“I was really interested in the medical field, but I didn’t feel like being a doctor was for me, so I was thinking of ways I could contribute without following that career path,” Dr Barzan says.

“I found the field of bioengineering would give me this opportunity, so I really like that I can play a part in this way.”

Heartfelt research for better medical devices

Dr Antony McNamee, a research fellow in the Griffith University Mechanobiology Lab

Dr Antony McNamee also nailed his pitch to take out the 2019 Fresh Scientist Award for best public presentation – focused on research to improve life support machines that keep people alive, but can also cause life-threatening complications.

Dr McNamee tests the BiVACOR total artificial heart

A blood physiologist in the Biorheology Research lab, Dr McNamee develops new and more sensitive techniques to detect red blood cell damage early, with the aim of improving heart-lung life support systems and artificial organs. He’s part of a team working with cardiothoracic surgeons and the medtech industry, including testing a world-first rotary artificial heart developed by Precinct company BiVACOR.

“This research area poses a challenging problem yet to be solved!” says Dr McNamee.

“It’s a fascinating field requiring skills in a number of areas, such as haematology, biophysics, and molecular biology. I get to work alongside some amazing teams in science, engineering, and medicine, to make discoveries that are working towards improving the lives of patients, all around the world.

In the future, artificial organs are going to be part of everyday medical treatment, and our research is helping this happen.

The opportunities are endless, as the health and knowledge precinct has amazing facilities and expertise at its fingertips!”

Dr Pizzolato with co-researcher Dr Dinesh Palipana OAM

Meanwhile, 2018 Fresh Science Judges Award winner Dr Claudio Pizzalato, now a Senior Research Fellow, is making strides in co-leading the novel BioSpine spinal injury rehabilitation research program, alongside Queensland Australian of the Year 2021, quadriplegic physician Dr Dinesh Palipana OAM.

With plans to commence a clinical trial involving a minimum of 5-6 people next year, the first stage of research has focused on customising a brain-computer interface (and Electroencephalogram or EEG) headset, with a virtual reality program to generate patient thought-control of a rehabilitation device, such as a motorised ergometer bike.

“The idea is the one of neuroplasticity,” Dr Pizzolato explains.

“We know we can remap our nervous system. We are using a brain-computer interface (BCI) and interpreting that data using artificial intelligence. That thought is then sent to a digital twin of the person, which controls the rehabilitation device.

The person is more empowered and feels control over their rehabilitation as that missing connection is being re-established.”

Watch our video below to learn more about the exciting medtech research emerging in the Precinct.

 

November 30, 2021 By Kathy Kruger

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